Spiral Artery Remodeling and Trophoblast Invasion in Preeclampsia and Fetal Growth Restriction
نویسندگان
چکیده
منابع مشابه
Spiral artery remodeling and trophoblast invasion in preeclampsia and fetal growth restriction: relationship to clinical outcome.
Failure to transform uteroplacental spiral arteries is thought to underpin disorders of pregnancy, including preeclampsia and fetal growth restriction (FGR). In this study, spiral artery remodeling and extravillous-cytotrophoblast were examined in placental bed biopsies from normal pregnancy (n = 25), preeclampsia (n = 22), and severe FGR (n = 10) and then compared with clinical parameters. Bio...
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Fetal growth restriction (FGR) and preeclampsia (PE) are often associated with abnormal maternal inflammation, deficient spiral artery (SA) remodeling, and altered uteroplacental perfusion. Here, we provide evidence of a novel mechanistic link between abnormal maternal inflammation and the development of FGR with features of PE. Using a model in which pregnant rats are administered low-dose lip...
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T he first observations that placental bed defects were potentially linked to clinical outcomes such as pre-eclampsia (PE) were made nearly 50 years ago. 1 This study followed prior findings that the placental clearance of radio-labeled saline was significantly decreased in women with hypertensive gestations. 2 Histological examination of pla-centas and placental bed biopsies obtained from comp...
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Background: To evaluate the effect of aspirin on preeclampsia and fetal growth restriction (FGR) in obese pregnant women. Methods: A randomized clinical trial with 187 participants. Participants were allocated to either an intervention (aspirin; n=89) or control (placebo; n=98) group. In two groups, intervention was done from 13-20 until 34 weeks of pregnancy. Outcomes were preeclampsia and FG...
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The present study was conducted to determine the impact of suppressing trophoblast remodeling of the uterine spiral arteries by prematurely elevating estrogen levels in the first trimester of baboon pregnancy on uterine and umbilical blood flow dynamics. Uteroplacental blood flow was assessed by Doppler ultrasonography after acute administration of saline (basal state) and serotonin on days 60,...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2013
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.113.01892